Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons

Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons

Autophagic/lysosomal dysfunction is a critical pathogenesis of neuronal injury after ischemic stroke. Trehalose has been validated to restore the impaired autophagy flux by boosting transcription factor EB (TFEB) nuclear translocation, but orally administrated trehalose can be greatly digested by in...

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Bibliographic Details
Main Authors: Zhiyuan Wu, Yongjie Zhang, Yuyuan Liu, Xuemei Chen, Zhiwen Huang, Xiaoming Zhao, Hongyun He, Yihao Deng
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Life
Subjects:
ischemic stroke
melibiose
TFEB nuclear translocation
autophagy flux
neuroprotection
Online Access:https://www.mdpi.com/2075-1729/11/9/948

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https://www.mdpi.com/2075-1729/11/9/948

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