Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

Abstract Novel therapies for hemophilia, including non‐factor replacement and in vivo gene therapy, are showing promising results in the clinic, including for patients having a history of inhibitor development. Here, we propose a novel therapeutic approach for hemophilia based on llama‐derived singl...

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Bibliographic Details
Main Authors: Elena Barbon, Gabriel Ayme, Amel Mohamadi, Jean‐François Ottavi, Charlotte Kawecki, Caterina Casari, Sebastien Verhenne, Solenne Marmier, Laetitia van Wittenberghe, Severine Charles, Fanny Collaud, Cecile V Denis, Olivier D Christophe, Federico Mingozzi, Peter J Lenting
Format: Article
Language:English
Published: Springer Nature 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
anticoagulation
coagulation
gene therapy
hemophilia
single‐domain antibodies
Online Access:https://doi.org/10.15252/emmm.201911298

Internet

https://doi.org/10.15252/emmm.201911298

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