Stimulation of antitumor immunity by FoxP3-targeting PROTAC

Stimulation of antitumor immunity by FoxP3-targeting PROTAC

CD4 + regulatory T cells (Tregs) play a central role in regulating and suppressing anti-tumor immune responses. FoxP3 is a transcription factor and master regulator of the Treg lineage. We developed and characterized a proteolysis targeting chimeric (PROTAC) drug that targets FoxP3 (PF). PF was crea...

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Bibliographic Details
Main Authors: Yanping Wang, Yi Zhang, Shengchen Su, Patrick Tamukong, Ramachandran Murali, Hyung L. Kim
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tregs
Checkpoint inhibitor
MTOR inhibitor
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006613

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http://www.sciencedirect.com/science/article/pii/S0753332223006613

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