Recent Zoonotic Spillover and Tropism Shift of a Canine Coronavirus Is Associated with Relaxed Selection and Putative Loss of Function in NTD Subdomain of Spike Protein

A canine coronavirus (CCoV) has now been reported from two independent human samples from Malaysia (respiratory, collected in 2017–2018; CCoV-HuPn-2018) and Haiti (urine, collected in 2017); these two viruses were nearly genetically identical. In an effort to identify any novel adaptations associate...

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Bibliographic Details
Main Authors: Jordan D. Zehr, Sergei L. Kosakovsky Pond, Darren P. Martin, Kristina Ceres, Gary R. Whittaker, Jean K. Millet, Laura B. Goodman, Michael J. Stanhope
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/14/5/853