Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-specific antiviral immunity, the molecula...

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Bibliographic Details
Main Authors: Siyuan Ding, William Khoury-Hanold, Akiko Iwasaki, Michael D Robek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3883642?pdf=render

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http://europepmc.org/articles/PMC3883642?pdf=render

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