Small cell lung cancer transformation and tumor heterogeneity after sequential targeted therapy and immunotherapy in EGFR-mutant non-small cell lung cancer: A case report

Small cell lung cancer transformation and tumor heterogeneity after sequential targeted therapy and immunotherapy in EGFR-mutant non-small cell lung cancer: A case report

BackgroundHistological transformation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is one of mechanisms of the acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI). However, SCLC transformation and tumor heterogeneity have never...

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Bibliographic Details
Main Authors: Meng-Hang Yang, Jia Yu, Chen-Lei Cai, Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
histologic transformation
tumor heterogeneity
immunotherapy
targeted therapy
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1029282/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1029282/full

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