MELK promotes HCC carcinogenesis through modulating cuproptosis-related gene DLAT-mediated mitochondrial function

Abstract Cuproptosis caused by copper overload is mediated by a novel regulatory mechanism that differs from previously documented mechanisms regulating cell death. Cells dependent on mitochondrial respiration showed increased sensitivity to a copper ionophore elesclomol that induced cuproptosis. Ma...

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Bibliographic Details
Main Authors: Zhipeng Li, Huaxin Zhou, Xiangyu Zhai, Lin Gao, Mengfan Yang, Baokun An, Tong Xia, Gang Du, Xiaoming Li, Wei Wang, Bin Jin
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06264-3