2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

Tau protein has been described for several decades as a promoter of tubulin assembly into microtubules. Dysregulation or alterations in Tau expression have been related to various brain cancers, including the highly aggressive and lethal brain tumor glioblastoma multiform (GBM). In this respect, Tau...

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Bibliographic Details
Main Authors: Rayane Hedna, Attilio DiMaio, Maxime Robin, Diane Allegro, Mario Tatoni, Vincent Peyrot, Pascale Barbier, Hervé Kovacic, Gilles Breuzard
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
2-aminothiazole
flavonoid
microtubule-associated protein Tau
glioblastoma
medicinal chemistry
Online Access:https://www.mdpi.com/1422-0067/24/20/15050

Internet

https://www.mdpi.com/1422-0067/24/20/15050

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