Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3

Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3

Arap3, a dual GTPase-activating protein (GAP) for the small GTPases Arf6 and RhoA, plays key roles in regulating a wide range of biological processes, including cancer cell invasion and metastasis. It is known that Arap3 is a PI3K effector that can bind directly to PI(3,4,5)P3, and the PI(3,4,5)P3-m...

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Bibliographic Details
Main Authors: Youjia Zhang, Liang Ge, Li Xu, Yongrui Liu, Jiarong Wang, Chongxu Liu, Hongxin Zhao, Lei Xing, Junfeng Wang, Bo Wu
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
Arap3
PH domain
complex structure
PI(3,4,5)P3
PI(4,5)P2
NMR
Online Access:https://www.mdpi.com/1422-0067/24/2/1125

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https://www.mdpi.com/1422-0067/24/2/1125

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