The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances

The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances

Abstract Immunotherapy has transformed the landscape of cancer treatment, with chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy emerging as a front runner in addressing some hematological malignancies. Despite its considerable efficacy, the occurrence of severe adverse effects assoc...

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Bibliographic Details
Main Authors: Pin Yao, Ya-Guang Liu, Gang Huang, Liangchun Hao, Runan Wang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Experimental Hematology & Oncology
Subjects:
Chimeric antigen receptor (CAR)
Single-chain variable fragment (scFv)
Natural killer cells
Major histocompatibility complex (MHC)
Tumor microenvironment (TME)
Induced pluripotent stem cell (iPSC)
Online Access:https://doi.org/10.1186/s40164-024-00583-7

Internet

https://doi.org/10.1186/s40164-024-00583-7

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