Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease

Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease

Sickle cell disease (SCD) is a serious global health problem, and currently, the only curative option is hematopoietic stem cell transplant (HCT). However, myeloablative total body irradiation (TBI)-based HCT is associated with high mortality/morbidity in SCD patients. Therefore, reduced-intensity (...

Full description

Bibliographic Details
Main Authors: Srideshikan Sargur Madabushi, Raghda Fouda, Hemendra Ghimire, Amr M. H. Abdelhamid, Ji Eun Lim, Paresh Vishwasrao, Stacy Kiven, Jamison Brooks, Darren Zuro, Joseph Rosenthal, Chandan Guha, Kalpna Gupta, Susanta K. Hui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
total marrow irradiation
bone marrow transplantation
sickle cell disease
engraftment
chimerism
mast cells
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.969429/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.969429/full

Similar Items