Mucosal Tuft Cell Density Is Increased in Diarrhea-Predominant Irritable Bowel Syndrome Colonic Biopsies

Mucosal Tuft Cell Density Is Increased in Diarrhea-Predominant Irritable Bowel Syndrome Colonic Biopsies

Tuft cells are rare chemosensory sentinels found in the gut epithelium. When triggered by helminth infection, tuft cells secrete interleukin-25 (IL-25) basolaterally and subsequently evoke an immune response. Irritable bowel syndrome (IBS) is a common and heterogeneous disorder characterized by bowe...

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Bibliographic Details
Main Authors: Jessica Aigbologa, Maeve Connolly, Julliette M. Buckley, Dervla O'Malley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Psychiatry
Subjects:
interleukin-25
irritable bowel syndrome
helminths
Wistar Kyoto
brush cells
Doublecortin Linked Kinase-1
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00436/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2020.00436/full

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