Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.
Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein, MutL homolog 1 (MLH1), and the mitochondrial...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Jezik: | English |
| Izdano: |
Public Library of Science (PLoS)
2022-01-01
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| Serija: | PLoS ONE |
| Online dostop: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268391&type=printable |