Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis.

Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis.

<h4>Background</h4>Intraamniotic inflammation is associated with up to 40% of preterm births, most notably in deliveries occurring prior to 32 weeks' gestation. Despite this, there are few treatment options allowing the prevention of preterm birth and associated fetal injury. Recent...

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Bibliographic Details
Main Authors: Yuki Takahashi, Masatoshi Saito, Haruo Usuda, Tsukasa Takahashi, Shimpei Watanabe, Takushi Hanita, Shinichi Sato, Yusaku Kumagai, Shota Koshinami, Hideyuki Ikeda, Sean Carter, Erin L Fee, Lucy Furfaro, Sylvain Chemtob, Jeffrey Keelan, David Olson, Nobuo Yaegashi, John P Newnham, Alan H Jobe, Matthew W Kemp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0257847

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https://doi.org/10.1371/journal.pone.0257847

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