Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice

Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice

Abstract Background Plenty of macrophages are recruited to the injured nerve to play key roles in the immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian degeneration, thus creating a conducive microenvironment for nerve regeneration. Recently, drugs targeting the R...

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Bibliographic Details
Main Authors: Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Neuroinflammation
Subjects:
RhoA
Macrophage
Wallerian degeneration
Nerve regeneration
Peripheral nerve injury
Online Access:https://doi.org/10.1186/s12974-021-02292-y

Internet

https://doi.org/10.1186/s12974-021-02292-y

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