Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures

Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures

Abstract Background Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be small and spindle-shaped but become...

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Bibliographic Details
Main Authors: S. Oja, P. Komulainen, A. Penttilä, J. Nystedt, M. Korhonen
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
MSC
Aging
Senescence
Quality control
Morphology
Online Access:http://link.springer.com/article/10.1186/s13287-017-0740-x

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http://link.springer.com/article/10.1186/s13287-017-0740-x

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