Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones

Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones

The synthesized 3,3-di(indolyl)indolin-2-ones 1a-p showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose. Particularly, compound 1i showed favorable higher α-glucosidase % inhibition of 67 ± 13 and lower α-amylase % inhibition...

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Bibliographic Details
Main Authors: Mardi Santoso, Li Lin Ong, Nur Pasca Aijijiyah, First Ambar Wati, Azminah Azminah, Rose Malina Annuur, Arif Fadlan, Zaher M.A. Judeh
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Heliyon
Subjects:
3,3-Di(indolyl)indolin-2-ones
Diabetes
α-glucosidase inhibition
α-amylase inhibition
Docking studies
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022003334

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http://www.sciencedirect.com/science/article/pii/S2405844022003334

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