Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.

Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.

The skin is an immune organ that contains innate and acquired immune systems and thus is able to respond to exogenous stimuli producing large amount of proinflammatory cytokines including IL-1 and IL-1 family members. The role of the epidermal IL-1 is not limited to initiation of local inflammatory...

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Bibliographic Details
Main Authors: Keiichi Yamanaka, Takehisa Nakanishi, Hiromitsu Saito, Junko Maruyama, Kenichi Isoda, Ayumu Yokochi, Kyoko Imanaka-Yoshida, Kenshiro Tsuda, Masato Kakeda, Ryuji Okamoto, Satoshi Fujita, Yoichiro Iwakura, Noboru Suzuki, Masaaki Ito, Kazuo Maruyama, Esteban C Gabazza, Toshimichi Yoshida, Motomu Shimaoka, Hitoshi Mizutani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4131904?pdf=render

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http://europepmc.org/articles/PMC4131904?pdf=render

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