Antimicrobial activity of human prion protein is mediated by its N-terminal region.

Antimicrobial activity of human prion protein is mediated by its N-terminal region.

BACKGROUND: Cellular prion-related protein (PrP(c)) is a cell-surface protein that is ubiquitously expressed in the human body. The multifunctionality of PrP(c), and presence of an exposed cationic and heparin-binding N-terminus, a feature characterizing many antimicrobial peptides, made us hypothes...

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Bibliographic Details
Main Authors: Mukesh Pasupuleti, Markus Roupe, Victoria Rydengård, Krystyna Surewicz, Witold K Surewicz, Anna Chalupka, Martin Malmsten, Ole E Sörensen, Artur Schmidtchen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2752989?pdf=render

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http://europepmc.org/articles/PMC2752989?pdf=render

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