Host IP3R channels are dispensable for rotavirus Ca2+ signaling but critical for intercellular Ca2+ waves that prime uninfected cells for rapid virus spread

Host IP3R channels are dispensable for rotavirus Ca2+ signaling but critical for intercellular Ca2+ waves that prime uninfected cells for rapid virus spread

ABSTRACTRotavirus is a leading cause of viral gastroenteritis. A hallmark of rotavirus infection is increased cytosolic Ca2+ caused by nonstructural protein 4 (NSP4). NSP4 is a viral ion channel that releases endoplasmic reticulum (ER) Ca2+, and the increased Ca2+ signaling is critical for rotavirus...

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Bibliographic Details
Main Authors: Jacob L. Perry, Francesca J. Scribano, John T. Gebert, Kristen A. Engevik, Jenna M. Ellis, Joseph M. Hyser
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
rotavirus
calcium signaling
replication
purinergic signaling
live imaging
Online Access:https://journals.asm.org/doi/10.1128/mbio.02145-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02145-23

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