Developing a peptide to disrupt cohesin head domain interactions

Developing a peptide to disrupt cohesin head domain interactions

Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head and hinge. ATP binding to the Smc heads induce...

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Bibliographic Details
Main Authors: Maria Elias, Samar Gani, Yana Lerner, Katreen Yamin, Chen Tor, Adarsh Patel, Avi Matityahu, Moshe Dessau, Nir Qvit, Itay Onn
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Protein
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015754

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223015754

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