Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by <i>Mycobacterium tuberculosis</i> and Helps Control the Phagosomal Replicative Niches

Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by <i>Mycobacterium tuberculosis</i> and Helps Control the Phagosomal Replicative Niches

<i>Mycobacterium tuberculosis</i> is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replication rates, they provide the swi...

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Bibliographic Details
Main Authors: David Pires, Manoj Mandal, Jacinta Pinho, Maria João Catalão, António José Almeida, José Miguel Azevedo-Pereira, Maria Manuela Gaspar, Elsa Anes
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
tuberculosis
phagosomal niches
survival strategies
cathepsins
saquinavir
protease inhibitors
Online Access:https://www.mdpi.com/1422-0067/24/2/1142

Internet

https://www.mdpi.com/1422-0067/24/2/1142

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