Inflammatory and interferon gene expression signatures in patients with mitochondrial disease

Inflammatory and interferon gene expression signatures in patients with mitochondrial disease

Abstract Background People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction may cause chronic inflammation, which may promote hyper-responsiveness...

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Bibliographic Details
Main Authors: Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West, Peter J. McGuire
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Anti-viral signaling
Inflammation
Interferon
Mitochondrial disease
PBMCs
Online Access:https://doi.org/10.1186/s12967-023-04180-w

Internet

https://doi.org/10.1186/s12967-023-04180-w

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