Exonuclease activity and P nucleotide addition in the generation of the expressed immunoglobulin repertoire

<p>Abstract</p> <p>Background</p> <p>Immunoglobulin rearrangement involves random and imprecise processes that act to both create and constrain diversity. Two such processes are the loss of nucleotides through the action of unknown exonuclease(s) and the addition of P n...

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Bibliographic Details
Main Authors: Sewell William, Gaeta Bruno, Jackson Katherine JL, Collins Andrew M
Format: Article
Language:English
Published: BMC 2004-09-01
Series:BMC Immunology
Online Access:http://www.biomedcentral.com/1471-2172/5/19