Microneedle-mediated transdermal delivery of FK506 for treatment of acute cardiac allograft rejection

Microneedle-mediated transdermal delivery of FK506 for treatment of acute cardiac allograft rejection

FK506 has been widely used to prevent acute rejection in heart transplantation (HT). However, its strong hydrophobicity, poor bioavailability, high pharmacokinetic variability, and narrow therapeutic window are obstacles to its application in HT. It has been demonstrated that localized and sustained...

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Bibliographic Details
Main Authors: Cheng Deng, Chenyuan Wang, Wenpei Fu, Lujuan Wu, Qiaofeng Jin, Li Zhang, Wen Zhang, Wei Li, Mingxing Xie
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Materials & Design
Subjects:
Heart transplantation
Acute rejection
FK506
Microneedle
Drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127523008304

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http://www.sciencedirect.com/science/article/pii/S0264127523008304

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