Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Rationale. Antibiotic treatment of patients infected with G- or G+ bacteria promotes release of the toxins lipopolysaccharide (LPS) and pneumolysin (PLY) in their lungs. Growth Hormone-releasing Hormone (GHRH) agonist JI-34 protects human lung microvascular cells (HL-MVEC), expressing splice variant...

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Bibliographic Details
Main Authors: Istvan eCzikora, Supriya eSridhar, Boris eGorshkov, Anita eKasa, Irina eAlieva, Joyce eGonzales, Olena ePotapenko, Nagavedi Siddaramappa Umapathy, Alexander D Verin, Helena ePillich, Ferenc G Rick, Norman L Block, Trinad eChakraborty, Michael A Matthay, Andrew V Schally, Rudolf eLucas
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Physiology
Subjects:
Protein Kinase C
lipopolysaccharide
growth hormone releasing hormone
protein kinase A
pneumolysin
endothelial barrier dysfunction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00259/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00259/full

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