VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells.

VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells.

Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by the accumulation of undifferentiated white blood cells (blasts) in the bone marrow. Valosin-containing protein (VCP) is an abundant molecular chaperone that extracts ubiquitylated substrates from protein complexes and cellul...

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Bibliographic Details
Main Authors: Paweł P Szczęśniak, Jan B Heidelberger, Hubert Serve, Petra Beli, Sebastian A Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0266478

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https://doi.org/10.1371/journal.pone.0266478

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