Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth

Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth

Gastrointestinal stromal tumors (GISTs) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most GISTs contain oncogenic KIT (85%) or PDGFRA (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatment for these tumors; however, the development of...

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Bibliographic Details
Main Authors: Eva Serrano‐Candelas, Erola Ainsua‐Enrich, Arnau Navinés‐Ferrer, Paulo Rodrigues, Alfonso García‐Valverde, Sarah Bazzocco, Irati Macaya, Joaquín Arribas, César Serrano, Joan Sayós, Diego Arango, Margarita Martin
Format: Article
Language:English
Published: Wiley 2018-08-01
Series:Molecular Oncology
Subjects:
apoptosis
gastrointestinal stromal tumors
KIT
PDGFRA
SH3BP2
Online Access:https://doi.org/10.1002/1878-0261.12332

Internet

https://doi.org/10.1002/1878-0261.12332

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