Design and Synthesis of 1-O- and 6′-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors

Design and Synthesis of 1-O- and 6′-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors

The extracellular human endo-6-O-sulfatases (Sulf-1 and Sulf-2) are responsible for the endolytic cleavage of the 6-sulfate groups from the internal D-glucosamine residues in the highly sulfated subdomains of heparan sulfate proteoglycans. A trisaccharide sulfate, IdoA2OS-GlcNS6S-IdoA2OS, was identi...

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Bibliographic Details
Main Authors: Kuei-Yao Tseng, Zheng-Hao Tzeng, Ting-Jen Rachel Cheng, Pi-Hui Liang, Shang-Cheng Hung
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Chemistry
Subjects:
heparan sulfate
glycosaminoglycans
endo-6-O-sulfatases
carbohydrate chemistry
inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.947475/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.947475/full

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