Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

We report the discovery of several highly potent small molecules with low-nM potency against severe acute respiratory syndrome coronavirus (SARS-CoV; lowest half-maximal inhibitory concentration (IC<sub>50</sub>: 13 nM), SARS-CoV-2 (IC<sub>50</sub>: 23 nM), and Middle East re...

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Bibliographic Details
Main Authors: Francesca Curreli, Shahad Ahmed, Sofia M. B. Victor, Aleksandra Drelich, Siva S. Panda, Andrea Altieri, Alexander V. Kurkin, Chien-Te K. Tseng, Christopher D. Hillyer, Asim K. Debnath
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
severe acute respiratory syndrome (SARS)
SARS-CoV
SARS-CoV-2
middle east respiratory syndrome (MERS)
MERS-CoV
COVID-19
Online Access:https://www.mdpi.com/1999-4915/14/1/69

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https://www.mdpi.com/1999-4915/14/1/69

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