Increased mitochondrial proton leak and glycolysis in peripheral blood mononuclear cells in type-1-diabetes

Increased mitochondrial proton leak and glycolysis in peripheral blood mononuclear cells in type-1-diabetes

Changes in cellular bioenergetics such as mitochondrial respiration and glycolysis may play a role in the pathogenesis of various diseases including type 1 diabetes (T1D). We used Seahorse extracellular flux technology to analyse the efficiency of glycolysis and mitochondrial oxidative phosphorylati...

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Bibliographic Details
Main Authors: Joana Mendes Lopes de Melo, Jens Christian Laursen, Niels Søndergaard-Heinrich, Ida Kirstine Bull Rasmussen, Christian Stevns Hansen, Marie Frimodt-Møller, Peter Rossing, Joachim Størling
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Heliyon
Subjects:
Type 1 diabetes (T1D)
Peripheral blood mononuclear cells (PBMCs)
Cellular bioenergetics
Seahorse extracellular flux technology
Glycolysis
Mitochondrial oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022035927

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http://www.sciencedirect.com/science/article/pii/S2405844022035927

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