Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice

De novo sterol synthesis is a critical homeostatic mechanism in the brain that begins during early embryonic development and continues throughout life. Multiple medications have sterol-biosynthesis-inhibiting side effects, with potentially detrimental effects on brain health. Using LC-MS/MS, we inve...

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Bibliographic Details
Main Authors: Luke B. Allen, Károly Mirnics
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/12/9/1211