Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy

Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy

Glioblastoma (GBM) is the most aggressive and lethal type of tumor in the central nervous system, characterized by a high incidence and poor prognosis. Thiotert, as a novel dual targeting agent, has potential inhibitory effects on various tumors. Here, we found that Thiotert effectively inhibited th...

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Bibliographic Details
Main Authors: Jianhong Dong, Yiming Qian, Wei Zhang, Qian Wang, Mengxian Jia, Juanqing Yue, Ziwei Fan, Yuanyuan Jiang, Lipei Wang, Yongjie Wang, Zhihui Huang, Lushan Yu, Ying Wang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Thiotert
Trx system
DNA damage
ER stress
Autophagy
GBM
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016657

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223016657

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