Biodistribution of the saponin-based adjuvant Matrix-M™ following intramuscular injection in mice

Biodistribution of the saponin-based adjuvant Matrix-M™ following intramuscular injection in mice

Novel adjuvants are extensively utilized in the development of safe and effective vaccines against emerging pathogens. Matrix-M™ adjuvant is a saponin-based adjuvant used in several active clinical development programs and in widespread use in the COVID-19 vaccine NVX-CoV2373. Here, we conducted a b...

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Bibliographic Details
Main Authors: Cecilia Carnrot, Berit Carow, Anna-Karin E. Palm, Eray Akpinar, Per-Henrik Helgesson, Ingrid Lekberg Osterman, Emelie Bringeland, Bryant Foreman, Nita Patel, Johan Bankefors, Louis Fries, Linda Stertman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Drug Delivery
Subjects:
vaccine
NVX-CoV2373
draining lymph node
vaccine safety
COVID-19
mechanism of action
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2023.1279710/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2023.1279710/full

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