Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy

Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy

Abstract Alternative oxidase (AOX) is a non‐mammalian enzyme that can bypass blockade of the complex III‐IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)‐deficient Bcs1lp.S78G knock‐in mice, displaying multiple visceral manifestations...

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Bibliographic Details
Main Authors: Jayasimman Rajendran, Janne Purhonen, Saara Tegelberg, Olli‐Pekka Smolander, Matthias Mörgelin, Jan Rozman, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Petri Auvinen, Eero Mervaala, Howard T Jacobs, Marten Szibor, Vineta Fellman, Jukka Kallijärvi
Format: Article
Language:English
Published: Springer Nature 2019-01-01
Series:EMBO Molecular Medicine
Subjects:
BCS1L
complex III
GRACILE syndrome
mitochondrial disorder
respiratory chain
Online Access:https://doi.org/10.15252/emmm.201809456

Internet

https://doi.org/10.15252/emmm.201809456

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