Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein

Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed to design and synthesize a new series of benzimidaz...

Full description

Bibliographic Details
Main Authors: Manar I. Nagy, Khaled M. Darwish, Safaa M. Kishk, Mohamed A. Tantawy, Ali M. Nasr, Mona Qushawy, Shady A. Swidan, Samia M. Mostafa, Ismail Salama
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
Bcl-2 inhibitors
Indole-based analogues
benzimidazole
MTT cytotoxic assay
cell cycle analysis
DNA fragmentation
Online Access:https://www.mdpi.com/1424-8247/14/2/113

Internet

https://www.mdpi.com/1424-8247/14/2/113

Similar Items