Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates

Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates

The pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter system facilitates the active net uptake of several marketed organic cationic drugs across the blood-brain barrier (BBB). This rare phenomenon has garnered interest in the H+/OC antiporter system as a potential target for CNS...

Full description

Bibliographic Details
Main Authors: Frida Bällgren, Yang Hu, Shannuo Li, Lara van de Beek, Margareta Hammarlund-Udenaes, Irena Loryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter
neurotoxicity
active uptake
blood-brain barrier
blood-spinal cord barrier
blood-CSF barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1493644/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2024.1493644/full

Similar Items