Impact of deoxycholate on Clostridioides difficile growth, toxin production, and sporulation

Purpose: Bile acids play an important role in Clostridioides difficile life cycle. Deoxycholate (DCA), one of the most abundant secondary bile acids, is known to inhibit vegetative growth and toxin production. However, limited data are available on the role of DCA on C. difficile sporulation. Here,...

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Bibliographic Details
Main Authors: Yukino Usui, Alafate Ayibieke, Yuko Kamiichi, Shu Okugawa, Kyoji Moriya, Shuji Tohda, Ryoichi Saito
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020305624