MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancersResearch in Context

MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancersResearch in Context

Background: Targeting of MDSCs is a major clinical challenge in the era of immunotherapy. Antibodies which deplete MDSCs in murine models can reactivate T cell responses. In humans such approaches have not developed due to difficulties in identifying targets amenable to clinical translation. Methods...

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Bibliographic Details
Main Authors: Livingstone Fultang, Silvia Panetti, Margaret Ng, Paul Collins, Suzanne Graef, Nagy Rizkalla, Sarah Booth, Richard Lenton, Boris Noyvert, Claire Shannon-Lowe, Gary Middleton, Francis Mussai, Carmela De Santo
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641930547X

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http://www.sciencedirect.com/science/article/pii/S235239641930547X

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