Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET Investigation

Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET Investigation

In the last few years, fluorescence resonance energy transfer (FRET) receptor sensors have contributed to the understanding of GPCR ligand binding and functional activation. FRET sensors based on muscarinic acetylcholine receptors (mAChRs) have been employed to study dual-steric ligands, allowing fo...

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Bibliographic Details
Main Authors: Carlo Matera, Michael Kauk, Davide Cirillo, Marco Maspero, Claudio Papotto, Daniela Volpato, Ulrike Holzgrabe, Marco De Amici, Carsten Hoffmann, Clelia Dallanoce
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
muscarinic acetylcholine receptors
Xanomeline
77-LH-28-1
bitopic hybrid ligands
synthesis
fluorescence resonance energy transfer
Online Access:https://www.mdpi.com/1420-3049/28/5/2407

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https://www.mdpi.com/1420-3049/28/5/2407

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