Synthesis, in vitro potency of inhibition, enzyme kinetics and in silico studies of quinoline-based α-glucosidase inhibitors

Synthesis, in vitro potency of inhibition, enzyme kinetics and in silico studies of quinoline-based α-glucosidase inhibitors

Abstract Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target α-glucosidase, which catalyzes starch hydrolysis in the intestine. In an attempt to...

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Bibliographic Details
Main Authors: Minoo Khalili Ghomi, Navid Dastyafteh, Mohammad Nazari Montazer, Milad Noori, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Seyedeh Mahdieh Hashemi, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-50711-2

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https://doi.org/10.1038/s41598-023-50711-2

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