Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

Choline kinase (ChoK) is the first enzyme of the Kennedy pathway leading to the biosynthesis of phosphatidylcholine (PtdCho), the most abundant phospholipid in eukaryotic cell membranes. EB-3D is a novel choline kinase α1 (ChoKα1) inhibitor with potent antiproliferative activity...

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Bibliographic Details
Main Authors: Elena Mariotto, Giampietro Viola, Roberto Ronca, Luca Persano, Sanja Aveic, Zaver M. Bhujwalla, Noriko Mori, Benedetta Accordi, Valentina Serafin, Luisa Carlota López-Cara, Roberta Bortolozzi
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
Choline Kinase α
breast cancer
small molecules
senescence
Online Access:http://www.mdpi.com/2072-6694/10/10/391

Internet

http://www.mdpi.com/2072-6694/10/10/391

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