Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis

Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis

Double-stranded RNA dependent kinase R (PKR) is originally identified as an intracellular sensor of viral infection, but its role in bacterial infection remains largely unknown. Here we report that PKR was an important regulator of antibacterial immunity in sepsis. Genetic deletion of PKR or pharmac...

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Bibliographic Details
Main Authors: Yanliang Yang, Lingli Xie, Yanjun Zhong, Xiaoli Zhong, Ran Meng, Qianqian Xue, Fang Liang, Kai Zhao, Yiting Tang
Format: Article
Language:English
Published: Karger Publishers 2020-12-01
Series:Journal of Innate Immunity
Subjects:
double-stranded rna dependent kinase r
bacterial sepsis
interleukin-1
Online Access:https://www.karger.com/Article/FullText/507932

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