Genetic Variations of the <i>DPYD</i> Gene and Its Relationship with Ancestry Proportions in Different Ecuadorian Trihybrid Populations

Genetic Variations of the <i>DPYD</i> Gene and Its Relationship with Ancestry Proportions in Different Ecuadorian Trihybrid Populations

Dihydropyrimidine dehydrogenase is one of the main pharmacological metabolizers of fluoropyrimidines, a group of drugs widely used in clinical oncology. Around 20 to 30% of patients treated with fluoropyrimidines experience severe toxicity caused by a partial or total decrease in enzymatic activity....

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Bibliographic Details
Main Authors: Camila Farinango, Jennifer Gallardo-Cóndor, Byron Freire-Paspuel, Rodrigo Flores-Espinoza, Gabriela Jaramillo-Koupermann, Andrés López-Cortés, Germán Burgos, Eduardo Tejera, Alejandro Cabrera-Andrade
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Journal of Personalized Medicine
Subjects:
fluoropyrimidines
<i>DPYD</i>
single nucleotide variants
pharmacogenetics
ancestry analysis estimation
Ecuadorian ethnic groups
Online Access:https://www.mdpi.com/2075-4426/12/6/950

Internet

https://www.mdpi.com/2075-4426/12/6/950

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