Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma

Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma

(1) Background: Previous findings show that lactam steroidal alkylating esters display improved therapeutic efficacy with reduced toxicity. The aim of this study was to evaluate the anticancer activity of two newly synthesized aza-steroid alkylators (ENGA-L06E and ENGA-L08E) against human ovarian ca...

Full description

Bibliographic Details
Main Authors: Panagiotis Dalezis, Eleni Geromichalou, Aikaterini Polonifi, Sofia Sagredou, Nikolaos Nikoleousakos, Michael Nikolaou, Vasiliki Sarli, Mihalis I. Panayiotidis, Dimitrios T. Trafalis
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
lactam steroidal alkylating esters
aniline-mustard alkylators
melphalan
ovarian carcinoma
xenografts
ERK
Online Access:https://www.mdpi.com/2072-6694/12/5/1263

Internet

https://www.mdpi.com/2072-6694/12/5/1263

Similar Items