Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and pattern formation in the Drosophila wing disc...

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Bibliographic Details
Main Authors: Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Fabian Gude, Daniele Di Iorio, Seraphine V. Wegner, Kay Grobe
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
hedgehog
morphogen
Drosophila
wing disc
heparan sulfate
QCM-D
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1130064/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1130064/full

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