The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

Serotonin communication operates mainly in the extracellular space and cerebrospinal fluid (CSF), using volume transmission with serotonin moving from source to target cells (neurons and astroglia) via energy gradients, leading to the diffusion and convection (flow) of serotonin. One emerging concep...

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Bibliographic Details
Main Authors: Dasiel O. Borroto-Escuela, Patrizia Ambrogini, Barbara Chruścicka, Maria Lindskog, Minerva Crespo-Ramirez, Juan C. Hernández-Mondragón, Miguel Perez de la Mora, Harriët Schellekens, Kjell Fuxe
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
G protein-coupled receptors
heteroreceptor complexes
serotonin receptor
oligomerization
oxytocin receptor
depression
Online Access:https://www.mdpi.com/1422-0067/22/4/1927

Internet

https://www.mdpi.com/1422-0067/22/4/1927

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