Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice

Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice

BackgroundEvery bout of exercise mobilizes and redistributes large numbers of effector lymphocytes with a cytotoxic and tissue migration phenotype. The frequent redistribution of these cells is purported to increase immune surveillance and play a mechanistic role in reducing cancer risk and slowing...

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Bibliographic Details
Main Authors: Helena Batatinha, Douglass M. Diak, Grace M. Niemiro, Forrest L. Baker, Kyle A. Smith, Tiffany M. Zúñiga, Preteesh L. Mylabathula, Michael D. Seckeler, Branden Lau, Emily C. LaVoy, Michael P. Gustafson, Emmanuel Katsanis, Richard J. Simpson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
exercise immunology
NSG mice
single cell transcriptomics
donor lymphocyte infusions
adoptive cell therapy
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1067369/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1067369/full

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