OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo

Generating engraftable hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) is an ideal approach for obtaining induced HSCs for cell therapy. However, the path from PSCs to robustly induced HSCs (iHSCs) in vitro remains elusive. We hypothesize that the modification of hematopoietic nic...

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Bibliographic Details
Main Authors: Xiaoli Chen, Qianhao Zhao, Chen Li, Yang Geng, Ke Huang, Jian Zhang, Xiaoshan Wang, Jiaqi Yang, Tongjie Wang, Chengxiang Xia, Xiaofei Liu, Minghui Meng, Dan Yang, Yi Zheng, Juan Du, Xiangzhong Zhang, Jiekai Chen, Guangjin Pan, Jinyong Wang
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Stem Cell Research
Subjects:
Hematopoietic progenitors
Pluripotent stem cells
OP9
Teratoma
Lhx2
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115001129

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http://www.sciencedirect.com/science/article/pii/S1873506115001129

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