NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells

NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells

Summary: The mechanism by which redox metabolism regulates the fates of acute myeloid leukemia (AML) cells remains largely unknown. Using a highly sensitive, genetically encoded fluorescent sensor of nicotinamide adenine dinucleotide phosphate (NADPH), iNap1, we find three heterogeneous subpopulatio...

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Bibliographic Details
Main Authors: Chiqi Chen, Xiaoyun Lai, Yaping Zhang, Li Xie, Zhuo Yu, Sijia Dan, Yu Jiang, Weicai Chen, Ligen Liu, Yi Yang, Dan Huang, Yuzheng Zhao, Junke Zheng
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Cell Reports
Subjects:
NADPH metabolism
metabolic sensor
acute myeloid leukemia
leukemia-initiating cells
endosteal niche
vascular niche
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722003552

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http://www.sciencedirect.com/science/article/pii/S2211124722003552

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